Antioxidant and anti-inflammatory activities of a commercial noni juice revealed by carrageenan-induced paw edema

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Yilmazer N., COSKUN C., Gurel-Gurevin E., Yaylim I., ERALTAN E. H. , Ikitimur-Armutak E. İ.

POLISH JOURNAL OF VETERINARY SCIENCES, cilt.19, ss.589-595, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/pjvs-2016-0074
  • Sayfa Sayıları: ss.589-595


This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product of noni (Morinda citrifolia) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control and three experimental groups were formed. Experimental groups were administered noni juice alone, noni juice+carrageenan, and carrageenan alone. Oxidant and antioxidant capacity were determined by d-ROMs test and BAP test, respectively. Plasma concentrations of endothelin-1 and leptin were measured by ELISA. Measurements were performed at zero time and 2nd hour of inflammation. Oxidant capacity decreased in noni-received groups at 2nd hour (p=0.019). Antioxidant capacity of the group which received noni alone was found to be higher at 2nd hour (p=0.036). Plasma concentrations of endothelin-1 and leptin were notably lower in noni-received groups (p=0.001 and p=0.021, respectively). The results show that the commercial noni juice investigated has pronounced antioxidant and anti-inflammatory activities.