This research focuses on the biocompatible zirconia, ceramic (ZrO2) material and load behavior causing fatigue on the surface of the dental implant in dentistry. Fatigue fracture and wear have been identified as some of the major problems associated with implant loosening, stress-shielding and ultimate implant failure. A static and cyclic fatigue testing of ceramic dental implant in laboratory conditions for this investigation were carried out according to the ISO protocol 14801 under worst-case conditions. A finite element analysis (PEA) of dental implant with accurate geometry and material properties were developed to make realistic investigations on biocompatibility of the implant biomaterial properties and mechanical fatigue behavior of new dental implant comparing Von-Mises criteria and maximum stress levels. The comparison of calculated fatigue life simulation data of and experimental data for the biocompatible zinconia, ceramic dental implants is presented. As a conclusion zirconium. implant exceeded the established values for maximum incisal bite forces reported in the literature and and also shows better performance than titanium implant material. The results of fatigue of biocompatible zirconia analysis are helpful for implant biomaterial selection and design for clinical interest: in dentistry.