HSP-10 in ovarian cancer: Expression and suppression of T-cell signaling


Akyol S. , Gercel-Taylor C., Reynolds L. C. , Taylor D. D.

GYNECOLOGIC ONCOLOGY, cilt.101, ss.481-486, 2006 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 101 Konu: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.ygyno.2005.11.014
  • Dergi Adı: GYNECOLOGIC ONCOLOGY
  • Sayfa Sayısı: ss.481-486

Özet

Objective. Suppressed T-cell activation is a hallmark of advanced ovarian cancer. Studies in pregnancy have demonstrated similar T-cell dysfunction mediated, at least in part, by HSP10, identified as "early pregnancy factor." This pilot study addresses the presence of HSP10 in the circulation of ovarian cancer patients and assesses its role in suppressing CD3-zeta.