Synthesis, computational study, and evaluation of in vitro antimicrobial, antibiofilm, and anticancer activities of new sulfanyl aminonaphthoquinone derivatives

Bayrak N. , Yildirim H., Tuyun A. F. , Kara E. M. , Celik B. O. , GUPTA G. K. , et al.

Letters in Drug Design and Discovery, cilt.14, ss.647-661, 2017 (SCI Expanded İndekslerine Giren Dergi)

  • Cilt numarası: 14 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1570180813666161020164931
  • Dergi Adı: Letters in Drug Design and Discovery
  • Sayfa Sayısı: ss.647-661


Background: A set of novel sulfanyl aminonaphthoquinone derivatives (5a-j) were synthesized starting from 2,3-dichloro-1,4-naphthoquinone (1). The amine substituents were introduced via a nucleophilic substitution at reflux temperature. Subsequent reactions of 2-chloro-3-arylamino-1,4-naphthoquinones (3a-d) with different thiols (4a-c) led to the formation of the desired amino-and thio-substituted products (5a-j).