Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.Purpose: The appropriate treatment of supratentorial low-grade gliomas (LGGs) is still a matter of discussion, and there have been yet no universal standard guidelines on how to manage these tumors, especially when they recur. This paper provides information on the efficacy of recurrent surgery in LGGs in long-term follow-up. Patients and Methods: Retrospective data related to a long-term follow-up of 13 patients in whom extensive resection of LGGs in both first and subsequent surgeries was provided. Results: Our data suggest that extensive resection and staged surgery has beneficial effects on survival and may delay malignant transformation. No patient in this series who was diagnosed with grade-III astrocytoma has received adjuvant therapy, namely chemotherapy and/or radiotherapy. Conclusions: Extensive resection in either the first or subsequent surgeries should be considered as the first line of treatment in patients with LGGs involving or located close to eloquent cortices or other deep-seated important structures even in the absence of intraoperative electrical stimulation. Adjuvant therapy, especially radiotherapy, should be questioned in those who have shown malignant transformation to grade-III. We underline that extended surgery would be the most effective therapy for LGG patients even in recurrent diseases.