Inflammatory Mediators Across the Spectrum of Ankle-Brachial Index

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Gur D. O. , GÜR Ö., Guzel S., Akyuz A., GÜRKAN S., ALPSOY Ş., et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.26, ss.351-361, 2019 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 26 Konu: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5551/jat.44891
  • Sayfa Sayısı: ss.351-361


Aim: Peripheral artery disease (PAD) is a manifestation of atherosclerosis with poor prognosis. It is generally complicated by vascular calcification, which is located either in the intima as patchy infiltrates; or circumferentially in the media, also known as medial arterial calcification (MAC). Obstructive PAD is reflected by low ankle-brachial index (ABI <= 0.9), whereas MAC is revealed by high ABI (ABI > 1.4). Considering the increase in cardiovascular mortality at both ends of the ABI spectrum, this study aimed to explore the underlying pathology through cytokines with established prognostic significance; namely pentraxin-3(PTX3), high sensitivity C-reactive protein (hsCRP), copeptin, soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), NT-proBNP, and neopterin.