Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence


Zanchetti A., Liu L., Mancia G., Parati G., Grassi G., Stramba-Badiale M., et al.

JOURNAL OF HYPERTENSION, cilt.32, ss.1741-1750, 2014 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 32 Konu: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1097/hjh.0000000000000253
  • Dergi Adı: JOURNAL OF HYPERTENSION
  • Sayfa Sayısı: ss.1741-1750

Özet

Background and objectives: It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.