The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat


Iseri S. O. , Ersoy Y., ERCAN F., YÜKSEL M., Atukeren P. , Gumustas K., et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.24, ss.1142-1148, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 24 Konu: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1111/j.1440-1746.2009.05797.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Sayfa Sayısı: ss.1142-1148

Özet

Sildenafil, a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE)5, has a relaxant effect on the smooth muscle cells of the arterioles supplying the human corpus cavernosum acting via nitric oxide (NO)-dependent mechanism. This study aimed to investigate the possible protective effect of sildenafil citrate on the extent of tissue integrity, oxidant-antioxidant status and neutrophil infiltration to the inflamed organ in a rat model of acetic acid-induced colitis.