Topical Treatment: Basic Rules and Absorbtion


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Aydemir E. H.

TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY, cilt.46, ss.117-120, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 46 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.4274/turkderm.000159
  • Dergi Adı: TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY
  • Sayfa Sayıları: ss.117-120

Özet

Topical treatment is applied as putting the medicines just on the problemmatic area of the skin. It is useful for avoiding the systemic side effects, decreasing the cost and it also works like an occupying treatment Absorbtion of active ingredient is a passive process and amount of absorption of active ingredient is affected by the properties of skin area applied and topical medicine itself. Absorption is more thinner, warmer and wetter areas of the skin.. Absorption is much more than needed, in the areas which are eroded and damaged. But, entrance of the topical medicine to the circulation is not useful and may cause systemic effects. Active ingredient in the topical medicine might have a high concentration, lipophilic nature and higher affinity to the skin than the affinity to the vehicle for a better absorbtion. Stages of absorbtion: Adsorbtion, absorbtion (penetration, permeation, resorbtion). Vehicles can be classified as liquids, semi solides and solides, but the classification as monophasic, biphasic and poliphasic is better (basicly mixtures of water-oils-powders).