Metformin suppresses the proliferation and invasion through NF-kB and MMPs in MCF-7 cell line


Besli N., Yenmis G., TUNÇDEMİR M. , Sarac E. Y. , Dogan S., Solakoglu S., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.45, ss.295-304, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 45 Konu: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/tjb-2019-0197
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.295-304

Özet

Objective: MCF-7 cells, a breast cancer cell line, are used for experiments of estrogen receptor (ER)-positive breast cancer and many sub-clones representing different classes of ER-positive tumors. We aimed to determine the efficacy of metformin, a potential anti-cancer agent, on the cell proliferation, and the expressions of NF-kB (p65), MM P-2 and MM P-9 in MCF-7 cell line.