Genetic variants of vitamin D metabolism-related <i>DHCR7/NADSYN1</i> locus and <i>CYP2R1</i> gene are associated with clinical features of Parkinson's disease.


Alaylioglu M. , Dursun E. , Genc G., Sengul B., BİLGİÇ B., Gunduz A. , ...Daha Fazla

The International journal of neuroscience, ss.1-11, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası:
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/00207454.2020.1820502
  • Dergi Adı: The International journal of neuroscience
  • Sayfa Sayıları: ss.1-11

Özet

Purpose/aim of the study: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Vitamin D deficiency is suggested to be related to PD. A genome-wide association study indicated that genes involved in vitamin D metabolism affect vitamin D levels. Among these genes, single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP/GC) genes have also been demonstrated to be associated with PD risk. Our aim was to investigate the relevance of SNPs within the 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) locus and vitamin D 25-hydroxylase (CYP2R1) gene, which encode important enzymes that play a role in the vitamin D synthesis pathway, with PD and its clinical features.