Wolff-Chaikoff effect in a newborn: is it an overlooked problem?

Aliefendioǧlu D., Şanli C., Çakmak M., Aǧar A., Albayrak M., EVLİYAOĞLU S. O.

Journal of Pediatric Surgery, cilt.41, sa.12, 2006 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Konu: 12
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jpedsurg.2006.08.041
  • Dergi Adı: Journal of Pediatric Surgery


Hypothyroidism is a serious endocrine disorder emerging from deficient production of thyroid hormone (thyroid gland agenesis or dysgenesis, or inborn metabolic defects of thyroid hormone production) or a defect in thyroid hormonal receptor activity. Prevention of iodine organification by means of using iodine-containing drugs or solutions is a protective mechanism for the body and is known as the Wolff-Chaikoff effect. This effect blocks thyroid hormone generation and is often transient, with thyroid hormone synthesis recovering in a few days or weeks. We present a neonate with transient thyroid dysfunction resulting from topical exposure to iodine-containing antiseptic solution. Our aim was to increase awareness that the use of antiseptic iodine solutions in neonates may result in transient hypothyroidism through the Wolff-Chaikoff effect and should be considered after the use of iodine-containing solutions or drugs. © 2006 Elsevier Inc. All rights reserved.