Analysis of the CC chemokine receptor 5 (CCR5) Delta 32 polymorphism in Behcet's disease


Yang X., Ahmad T., Gogus F., Wallace G., Madanat W., Kanawati C., ...Daha Fazla

EUROPEAN JOURNAL OF IMMUNOGENETICS, cilt.31, ss.11-14, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 31 Konu: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1365-2370.2004.00444.x
  • Dergi Adı: EUROPEAN JOURNAL OF IMMUNOGENETICS
  • Sayfa Sayıları: ss.11-14

Özet

Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behcet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.