The effects of systemic and intratumoral interleukin-12 treatment in C6 rat glioma model


Tanriover N. , Ulu M. O. , Sanus G. Z. , Bilir A., Canbeyli R., Oz B. , et al.

NEUROLOGICAL RESEARCH, cilt.30, ss.511-517, 2008 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 30 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1179/174313208x289516
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Sayfa Sayısı: ss.511-517

Özet

Objective: Cytokine based immunotherapy has long been an exciting field for many investigators aiming to provide an effective alternative treatment modality for glioma management. Among these cytokines, interleukin-12 (IL-12) plays a crucial role in mediating inflammatory and antitumoral activity on the host defence. We have investigated the therapeutic role of systemic and local delivery of IL-12 in C6 rat glioma model and compared these two modalities.