Synergistic effect of butyrate on platelet responses to arachidonate

Ulutin T. , Kanigur-Sultuybek G., Cenani A.

Klinik Gelisim, cilt.6, sa.11, ss.2748-2751, 1993 (Diğer Kurumların Hakemli Dergileri) identifier

  • Cilt numarası: 6 Konu: 11
  • Basım Tarihi: 1993
  • Dergi Adı: Klinik Gelisim
  • Sayfa Sayıları: ss.2748-2751


With eucaryotic cells, butyrate is known to induce a series of morphological and biochemical changes that mimic cellular differentiation. With platelets, we have found that butyrate (10 mmol/l) caused an approximately threefold increase in sensitivity to calcium ionophore A 23187 and arachidonate. Maximum aggregation was observed at agonist concentrations of 3 μmol/l and 170 μmol/l, respectively, as compared with required concentrations of 10 μmol/l and 400 μmol/l in the absence of butyrate. No ultrastructural changes were observed in platelets incubated with butyrate, and the aggregation effects were reversible and returned to normal on removal of butyrate. Butyrate caused a 60% to 70% increase in the uptake of 3H-arachidonate. These results suggest that butyrate may increase the uptake of certain hydrophobic agonists and antagonists by platelets.