Çocuk Acil ve Yoğun Bakım Dergisi, cilt.5, sa.3, ss.99-106, 2018 (Diğer Kurumların Hakemli Dergileri)
Introduction: We have limited information about the clinical
importance of plasma B-type natriuretic peptide (BNP) level and
its prognostic value in children with bronchiolitis. In this study, we
aimed to determine basal plasma BNP levels and their relationship
with left ventricular systolic functions and prognosis in patients
hospitalized with moderate to severe bronchiolitis.
Methods: The study was conducted prospectively on 37 patients
aged 1-24 months with a modified Wang respiratory score of 6
and above and diagnosed with bronchiolitis. The patients with high
(>100 pg/mL, n=6) and normal (≤100 pg/mL, n=31) serum BNP
levels were compared in terms of left ventricular systolic functions,
and vital, laboratory, and radiological findings. The relationship
between serum BNP level and prognosis was evaluated.
Results: The mean basal plasma BNP level in the patients was
significantly higher than in controls (61.75±65 pg/mL vs. 13.99±8.79
pg/mL; p=0.001). There was no significant difference in ejection
fraction and fractional shortening values between the patients with
normal and high BNP levels and controls (p>0.05). Patients with
high BNP levels had higher mean partial carbon dioxide values than
patients with normal BNP levels (p=0.037). There was a positive
correlation between plasma BNP level and length of hospital stay
(r=0.286; p=0.007) and intensive care unit stay (r=0.645; p=0.000).
Conclusion: An increase in serum BNP levels may be seen in
patients with moderate to severe bronchiolitis without myocardial
dysfunction. It was argued that this BNP increase may be related
to the degree of deterioration of gas exchange associated with the
disease. Plasma BNP level is a potential prognostic factor in moderate
to severe bronchiolitis.
Keywords: Bronchiolitis, infant, B-type natriuretic peptide,
myocardial dysfunction, prognosis