B-Type Natriuretic Peptide in Bronchiolitis: Its Relationship with Left Ventricular Systolic Functions and Prognosis


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Kes G.

Çocuk Acil ve Yoğun Bakım Dergisi, cilt.5, sa.3, ss.99-106, 2018 (Diğer Kurumların Hakemli Dergileri)

  • Cilt numarası: 5 Konu: 3
  • Basım Tarihi: 2018
  • Dergi Adı: Çocuk Acil ve Yoğun Bakım Dergisi
  • Sayfa Sayıları: ss.99-106

Özet

Introduction: We have limited information about the clinical

importance of plasma B-type natriuretic peptide (BNP) level and

its prognostic value in children with bronchiolitis. In this study, we

aimed to determine basal plasma BNP levels and their relationship

with left ventricular systolic functions and prognosis in patients

hospitalized with moderate to severe bronchiolitis.

Methods: The study was conducted prospectively on 37 patients

aged 1-24 months with a modified Wang respiratory score of 6

and above and diagnosed with bronchiolitis. The patients with high

(>100 pg/mL, n=6) and normal (≤100 pg/mL, n=31) serum BNP

levels were compared in terms of left ventricular systolic functions,

and vital, laboratory, and radiological findings. The relationship

between serum BNP level and prognosis was evaluated.

Results: The mean basal plasma BNP level in the patients was

significantly higher than in controls (61.75±65 pg/mL vs. 13.99±8.79

pg/mL; p=0.001). There was no significant difference in ejection

fraction and fractional shortening values between the patients with

normal and high BNP levels and controls (p>0.05). Patients with

high BNP levels had higher mean partial carbon dioxide values than

patients with normal BNP levels (p=0.037). There was a positive

correlation between plasma BNP level and length of hospital stay

(r=0.286; p=0.007) and intensive care unit stay (r=0.645; p=0.000).

Conclusion: An increase in serum BNP levels may be seen in

patients with moderate to severe bronchiolitis without myocardial

dysfunction. It was argued that this BNP increase may be related

to the degree of deterioration of gas exchange associated with the

disease. Plasma BNP level is a potential prognostic factor in moderate

to severe bronchiolitis.

Keywords: Bronchiolitis, infant, B-type natriuretic peptide,

myocardial dysfunction, prognosis