NEUROLOGY, cilt.57, ss.1675-1678, 2001 (SCI İndekslerine Giren Dergi)
Objective: To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP).
Background: LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases,
especially AD. Methods: The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98
normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for -synuclein. Results: LB and Lewy
neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and
amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was
comparable to the frequency of LB in controls (9%). Conclusions: In contrast to increased frequency of LB in AD, there is
no apparent interaction between LB and the tau pathology in PSP.