Association between MTHFR C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer


Ozkilic A. C. , Cetin A., Bayoglu B. , Balci H. , Cengiz M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.41, ss.459-465, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 41 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/tjb-2016-0151
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.459-465

Özet

Objective: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the metabolism of methionine and folate. MTHFR C677T polymorphism was reported to be associated with breast and ovarian cancer. The aim of this study was to evaluate the association between the MTHFR C677T (rs1801133) polymorphism and homocysteine, vitamin B-12, and folate levels, and DNA fragmentation in patients with ovarian cancer and healthy controls.