Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

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Balci H., Erdem T. Y. , Ugurlu S., Yetkin D. O. , Bolayirli İ. M. , Hacibekiroglu M., ...Daha Fazla

Central European Journal of Medicine, cilt.6, ss.158-162, 2011 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 6 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2478/s11536-010-0036-3
  • Dergi Adı: Central European Journal of Medicine
  • Sayfa Sayıları: ss.158-162


Thyroid status is known to influence growth in mammals. The aim of thisstudy is to investigate the possible relationship between autoimmune subclinical hypothyroidism and growth hormone (GH), insulin-likegrowth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) levels. Thirty-five women with autoimmune subclinical hypothyroidism, 33 years of age, were used as controls and enrolled in the study. Free triiodothyronin (FT3), free thyroxin(FT4), thyrotropin(TSH), anti-thyroid peroxidase(Anti-TPO), anti-thyroglobuline(Anti-Tg), GH, IGF-1 and IGFBP-3 levels were measured in blood samples and correlations among these parameters were evaluated. We found no significant differences in GH, IGF-1 or IGFBP-3 between patients and controls. In patients and controls, there were no correlations among thyroid hormones and IGF-1 or IGFBP-3 levels, but GH levels were correlated with FT3, FT4 and TSH only in patients' group. In controls, only IGF-1 and IGFBP-3 levels were correlated. The present study suggests that subclinical hypothyroidism with high TSH and antibody status does not affect IGF-1 and IGFBP-3 levels in adult women. To our knowledge, this is the first study concerning the relationship between autoimmune subclinical hypothyroidism and IGF-1 and IGFBP-3 levels.© Versita Sp. z o.o.