INHIBITORY EFFECT OF ALLOPURINOL ON ADJUVANT ARTHRITIS IN RATS


MELLI M., YAZICI H., UCAR A., TURKER R.

AGENTS AND ACTIONS, cilt.42, ss.56-59, 1994 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 42
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1007/bf02014301
  • Dergi Adı: AGENTS AND ACTIONS
  • Sayfa Sayısı: ss.56-59

Özet

The effect of Allopurinol (ALLO), on adjuvant arthritis was studied in rats and compared with the effect of indomethacin (IND). Drugs were given by intraperitoneal injection for each day beginning from the day of adjuvant injection (day 0) and continued until the 16th day. Paw swelling was measured on days 4, 17 and 29, and secondary lesions were assessed on days 17 and 29. Polymorphonuclear leukocyte (PMNs) count was also evaluated on day 17.