Is metoclopramide an alternative to tramadol in management of post-operative pain? An experimental study


Ceyhan A., Ustun H., Altunatmaz K. , Ide T., Unal N.

JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE, cilt.52, no.1, ss.249-253, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier identifier

  • Cilt numarası: 52 Konu: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1439-0442.2005.00719.x
  • Dergi Adı: JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE
  • Sayfa Sayıları: ss.249-253

Özet

In this study, metoclopramide was compared with other pharmacological agents for preventing post-operative pain. Sixty Sprague-Dawley male rats, weighing 310-345 g were included in the study; 1 cm surgical incision, including skin, facia, and muscle was made to the plantar surface of rear foot of all anaesthetized rats. Rats were randomized into four groups. In group 1 (group S) 2 cm(3) saline, in group 2 (group M) 2 cm(3) metoclopramide (5 mg/kg) in group 3 (group T) 2 cm(3) tramadol (45 mg/kg), in group 4 (group M + T) half doses of group M and group T was given intraperitoneally. Post-operative pain was assessed after 2 h, first and second days of incision. Post-operative pain scores were found to be significantly lower in group M, group T and group M + T when compared with the control group. But there was no significant difference between these groups. We concluded that metoclopramide, with low cost, fewer side-effects and being significantly effective for preventing post-operative pain, can be an alternative to tramadol.