INCREASED CHITOTRIOSIDASE ACTIVITIES IN PATIENTS WITH RHEUMATOID ARTHRITIS: A POSSIBLE NOVEL MARKER?


Basok B. I. , Kucur M. , Kizilgul M., Yilmaz I., Ekmekci O. B. , Uzunlulu M., et al.

JOURNAL OF MEDICAL BIOCHEMISTRY, cilt.33, ss.245-251, 2014 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 33 Konu: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.2478/jomb-2014-0010
  • Dergi Adı: JOURNAL OF MEDICAL BIOCHEMISTRY
  • Sayfa Sayısı: ss.245-251

Özet

Background: Chitotriosidase and YKL-40 are well-known in humans as Glyco_18 domain-containing proteins that are the common feature of mammalian chitinases and chitinase-like proteins. Previously, increased levels of YKL-40 were found correlated with the disease activity of rheumatoid arthritis. However, serum chitotriosidase activity in rheumatoid arthritis is not known yet. The aim of this study was to determine YKL-40 and chitotriosidase in patients with rheumatoid arthritis and to compare these markers with traditional ones such as C-reactive protein and erythrocyte sedimentation rate.