We evaluated fungal decay and mold resistance, leaching, and water absorption of nano-compounds and Paraloid B72(A (R)) (PB72) in treated wood specimens to develop new methods of consolidation by combining nano-particles and consolidants. Scots pine wood specimens were treated with dispersions of nano-CuO, nano-ZnO, nano-B2O3, nano-TiO2, and nano-CeO2. PB72 treatments of nano-particle-treated wood specimens were then carried out by either vacuum or immersion for 24 h. Previously, decayed wood specimens were also consolidated with the nano-compounds and PB72. PB72 treatments reduced element release from treated wood specimens. Nearly all nano-compounds + PB72 treatments increased the biological performance of treated wood specimens against decay fungi tested. PB72-only treated wood specimens had the highest weight losses in decay tests. No improvements were obtained in mold resistance tests when the nano-compounds and PB72 were combined. In nano-compound-only treatments, unleached specimens showed slightly lower water absorption values compared to untreated control specimens. Incorporation of PB72 into nano-compound-treated wood specimens resulted in considerably lower water absorption and volumetric swell. In previously decayed specimens treated with the nano-compounds and PB72 solution, water absorption after 2-h immersion declined compared to control specimens.