Effect of acute hyperglycemia on potassium (Rb-86(+)) permeability and plasma lipid peroxidation in subjects with normal glucose tolerance

Guven M., Onaran I. , Ulutin T. , Sultuybek G., Hatemi H.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.24, no.4, pp.231-235, 2001 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 2001
  • Page Numbers: pp.231-235


Hyperglycemia is likely to be one of the important determinants of ion transport as it is known to induce oxidative stress and may thus enhance non-specific permeability of membranes. The aim of the present study was to evaluate the effects of an acute increase in glycemia on Rb-86(+) (a marker for K+) influx and lipid peroxidation. We evaluated the 75-g oral glucose tolerance test (OGTT)-induced modification on Rb-86(+) influx and plasma lipid peroxidation in 20 subjects with normal glucose tolerance (NGT). After 2-hour glucose loading, the levels of passive Rb-86(+) influx and plasma lipid peroxidation were significantly increased, whereas the active influx of Rb-86(+) was unchanged. The total and passive influx of Rb-86(+) into erythrocytes was significantly correlated with the level of plasma lipid peroxidation. This study demonstrates that acute hyperglycemia induces an increase in the passive influx of Rb-86(+) in subjects with NGT, suggesting that acute hyperglycemia may produce an oxidative stress in plasma. These changes may be among the earliest changes occurring in response to hyperglycemia. ((C))2001, Editrice Kurtis.