Owerview on Coumarin Chalcone Compounds and Properties Synthesized in 2020


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Çelik Onar H.

in: Academic Research And Reviews in Science and Mathematics, Berkan Balpetek,Assist Prof. Mine SULAK Ph.D, Editor, Duvar Publishing, İzmir, pp.35-54, 2021

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2021
  • Publisher: Duvar Publishing
  • City: İzmir
  • Page Numbers: pp.35-54
  • Editors: Berkan Balpetek,Assist Prof. Mine SULAK Ph.D, Editor

Abstract

Chalcones, generally composed of two aromatic rings connected α, β-unsaturated carbonyl system which a threecarbon, are naturally found in vegetables, fruits, teas and other plants and are involved in the biosynthesis of isoflavonoids and flavonoids in plants (Rashid et al., 2019). They are very important class because of medicinal and pharmacological properties like anticancer (Modzelewska et al., 2006), antitumor (Jin et al., 2013), anti-diabetics (Ugwu et al., 2015), anti-HIV (Rizvi et al., 2012), antioxidants (Mazzone et al., 2015), antiulcer (Sashidhara et al., 2015), antimalarial (Raj et al., 2015), cardiovascular (Mahapatra and Bharti, 2016), anti-tubercular (Mujahid et al., 2015), antibacterial (Mujahid et al., 2015), antifungal (Zheng et al., 2015), antiviral (Zhou et al., 2018), anti-inflammatory (Mahapatra et al., 2017), anticonvulsant (Sharma et al., 2013), antidiuretic (Rizvi et al., 2012). Naturally derived chalcones are usually yellow, orange and brown colored crystalline solids. Coumarin composed of benzene and 2-pyron rings is a bicyclic heterocyclic compound and is also a broad natural class. Coumarin derivatives show a lot of pharmacological activities (Sashidhara et al., 2013; Emami and Dadashpour, 2015), such as anticarcinogenic (Basanagouda et al., 2014), antiviral (Curini et al., 2003), anticholinesterase (Kurt et al., 2015), antiinflammatory (Fylaktakidou et al., 2004), antithrombotic (Peng et al., 2013), antioxidant (Kostova et al., 2011), hepatoprotective (Atmaca et al., 2011), , antimicrobial (Ostrov et al., 2007), antituberculosis (Manvar et al., 2011), antihyperlipidemic (Yuce et al., 2009) and monoamine oxidase-B inhibitors (Hammuda et al., 2016) activities.