The effects of chemotherapeutic agents on differentiated chordoma cells

Bayrak O. F. , Aydemir E., Gulluoglu S., Sahin F., Sevli S., Yalvac M. E. , ...Daha Fazla

JOURNAL OF NEUROSURGERY-SPINE, cilt.15, sa.6, ss.620-624, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3171/2011.7.spine10798
  • Sayfa Sayıları: ss.620-624


Object. Chordoma is a rare type of malignant bone tumor and is known to arise from the remnants of the notochord. Resistance to chemotherapy makes the treatment of chordoma difficult; therefore, new approaches need to be developed to cure this disease. Differentiation therapy, using various differentiating agents, is attracting oncologists as a common therapeutic method to treat other tumors. Based on forcing cells to mature into other lineages, differentiation therapy might be an available method to treat chordomas in addition to conventional therapies.