Co-existence of multiple sclerosis and anti-NMDA receptor encephalitis: A case report and review of literature


Gulec B., Kurucu H., Bozbay S., Dikmen Y. , Sayman H. B. , TÜZÜN E., ...More

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.42, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 42
  • Publication Date: 2020
  • Doi Number: 10.1016/j.msard.2020.102075
  • Title of Journal : MULTIPLE SCLEROSIS AND RELATED DISORDERS

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a serious autoimmune disorder characterized by psychiatric symptoms, seizures and movement disorder. Predisposing factors have been reported since the time it was described, and its pathophysiology has been tried to be clarified over the years. Although overlap with other demyelinating diseases had been reported, such an association between Multiple Sclerosis (MS) anti ANT?- NMDAR encephalitis is limited to only a few case reports. In this article, a patient diagnosed with relapsing remitting multiple sclerosis (RRMS) for ten years who then developed NMDA-R encephalitis while on disease modifying treatment will be presented and possible common pathophysiology with previously reported litera- ture will be discussed.