Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis

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Tutuncu M. , Tang J., Abou Zeid N., Kale N., Crusan D. J. , Atkinson E. J. , ...Daha Fazla

MULTIPLE SCLEROSIS JOURNAL, cilt.19, ss.188-198, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1177/1352458512451510
  • Sayfa Sayıları: ss.188-198


Background: It is unclear if all patients with relapsing remitting multiple sclerosis (RRMS) ultimately develop progressive MS. Onset of progressive disease course seems to be age- rather than disease duration-dependent. Some forms of progressive MS (e.g. primary progressive MS (PPMS)) are uncommon in population-based studies. Ascertainment of patients with PPMS from clinic-based populations can facilitate a powerful comparison of age at progression onset between secondary progressive MS (SPMS) and PPMS but may introduce unclear biases.