Background: LPG endermologie is a worldwide FDA-approved massage system used in the treatment of cellulite. Objective: The aim of this study is to evaluate safety, efficacy, and the slimming potential of LPG endermologie. Material and methods: A total of 118 women (mean age, 34.59 +/- 8.02 years) were enrolled in this study. The LPG treatment sessions were performed twice weekly and continued for at least 15 sessions. The outcome was clinically evaluated using digital photography for cellulite grade assessment while perimetric measurements for eight body sites were performed. The evaluation also included measurements of body weight and body fat percentage (BFP). Results: One hundred and seventeen patients (99%) showed loss in body circumference measurements. A mean body circumference reduction of 2.9 +/- 1.6 cm was obtained per site for all patients. There was a mean body circumference loss which was statically significant with p < 0.001. Weight loss was detected in one hundred and three patients (87%). The mean body weight loss was 2.717 +/- 1.938 kg for all patients. One hundred and ten subjects (93%) also showed decreases in BFP. The questionnaire indicated high satisfaction in 81 (69%) patients. Conclusion: LPG endermologie is a well-tolerated and effective alternative treatment modality for slimming and body contouring.