Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G


Koseoglu V., Kismet E., Soysal Y., Ulucan H. , Dundaroz R., Imirzahoglu N., et al.

PEDIATRICS INTERNATIONAL, cilt.46, ss.415-418, 2004 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 46 Konu: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1442-200x.2004.01930.x
  • Dergi Adı: PEDIATRICS INTERNATIONAL
  • Sayfa Sayısı: ss.415-418

Özet

Background: Benzathine penicillin G (BPG) is a widely used antibiotic for treatment or prophylaxis of certain infectious diseases. Previous in vivo studies using sister chromatid exchange (SCE) frequency and comet assay, had showed that long-term administration of benzathine penicillin G may cause some degree of DNA damage in children with rheumatic fever.