Potential effects of L-NAME on alcohol-induced oxidative stress


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Uzun H. , Simsek G., Aydin S. , Unal E., Karter Y., Yelmen N. K. , et al.

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.11, ss.600-604, 2005 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 11 Konu: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.3748/wjg.v11.i4.600
  • Dergi Adı: WORLD JOURNAL OF GASTROENTEROLOGY
  • Sayfa Sayısı: ss.600-604

Özet

AIM: Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nw-nitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 wk-period.