Alterations in oxygen radicals producing and scavenging enzymes in vitamin E and carbon tetrachloride treated rats


Belce A., Gumustas M. K. , Altug T., Kokoglu E., Aslan M., Dincer I., ...Daha Fazla

Medical Bulletin of Istanbul Medical Faculty, cilt.27, sa.2, ss.19-21, 1994 (Diğer Kurumların Hakemli Dergileri) identifier

  • Cilt numarası: 27 Konu: 2
  • Basım Tarihi: 1994
  • Dergi Adı: Medical Bulletin of Istanbul Medical Faculty
  • Sayfa Sayıları: ss.19-21

Özet

CCl4 is bioactivated by cytochrome P-450 and trichloromethyl radical is formed. Our aim was to investigate how CCl4 and vitamin E treatments affect oxidant (XO) and antioxidant enzymes SOD, CAT, GP status in rat blood and liver tissues. Our results show that generally CCl4 treatment doesn't cause significant alterations on both blood and liver enzymes we studied. Furthermore, vitamin E treatment neither before CCl4 treatment nor together CCl4 doesn't make significant differences on the activities of above enzymes.