Modified risk associations of lipoproteins and apolipoproteins by chronic low-grade inflammation


Onat A., Kaya A. , Ademoglu E.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY, cilt.16, ss.39-48, 2018 (ESCI İndekslerine Giren Dergi)

  • Cilt numarası: 16 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/14779072.2018.1417839
  • Dergi Adı: EXPERT REVIEW OF CARDIOVASCULAR THERAPY
  • Sayfa Sayısı: ss.39-48

Özet

Introduction: Lipoproteins and the apolipoproteins (apo) that they carry are major determinants of cardiovascular diseases (CVD) as well as metabolic, renal and inflammatory chronic disorders either directly or through mediation of risk factors. The notion that elevated low-density lipoprotein cholesterol (LDL-C) and apoB levels are related to the acquisition of CVD and, high-density lipoprotein cholesterol (HDL-C) and apoA-I indicate protection against CVD has been challenged in the past decade. Advanced age, adiposity, ethnicity or impaired glucose intolerance rendered autoimmune activation in an environment of pro-inflammatory state/oxidative stress and may disrupt the linear risk association between lipoproteins.