Subcutaneous cryptococcosis due to Cryptococcus diffluens in a patient with sporotrichoid lesions case report, features of the case isolate and in vitro antifungal susceptibilities

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Kantarcioglu A. S. , Boekhout T., De Hoog G. S. , Theelen B., Yucel A., Ekmekci T. R. , et al.

MEDICAL MYCOLOGY, cilt.45, ss.173-181, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 45 Konu: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/13693780601045166
  • Sayfa Sayısı: ss.173-181


Environmental fungi, in particular primary pathogens and Cryptococcus spp. can be responsible for skin lesions mimicking sporotrichosis. In this paper, we report a case of subcutaneous cryptococcosis in an apparently healthy young male patient due to a non-C. neoformans Cryptococcus species, C. diffluens. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. This species shares several phenotypic traits with C. neoformans, and, therefore, decisive diagnosis should be based on biopsy and culturing results followed by molecular identification.