Attenuation of ischemia/reperfusion injury by N-acetylcysteine in a rat hind limb model


Koksal C., Bozkurt A., Cangel U., Ustundag N., Konukoglu D. , Musellim B., et al.

JOURNAL OF SURGICAL RESEARCH, cilt.111, ss.236-239, 2003 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 111 Konu: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0022-4804(03)00094-5
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayısı: ss.236-239

Özet

Background. Ischemia/reperfusion is a complex set of events with severe pathologic consequences. Reperfusion initiates both the local and systemic damage in part through rapid oxygen generation. N-acetylcysteine (NAC) is a scavenger of free radical species, inhibits neutrophil accumulation, acts as a vasodilator and also improves microcirculation. In present study, we examined the protective effect of NAC in a rat hind limb ischemia/reperfusion model. Dimethyl-sulfoxide (DMSO), a well-known antioxidant was also tested for comparison.