Intracranial hypertension related to cerebral venous thrombosis; and acute ischemic stroke with micro-infarcts associated with IgG4-related disease

Ekizoglu E., Coban O., Ulukan C., Ak D. , Dursun E. , Tuzun E., ...Daha Fazla

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.128, sa.11, ss.1097-1099, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 128 Konu: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/00207454.2018.1458728
  • Sayfa Sayıları: ss.1097-1099


IgG4-related systemic disease (IgG4-RD) is characterized by an inflammatory reaction rich in IgG4-positive plasma cells, affecting multiple organs. This report describes a case who was diagnosed with IgG4-RD, having cerebral venous thrombosis and a subsequent acute ischemic stroke of undetermined cause. A 47-year-old woman presented with headache, visual disturbance and eyelid swelling and two years later she was admitted with acute attacks of mild left lower limb sensory-motor monoparesis. Indirect immunohistochemistry assay showed elevated level of IgG4, labeling neurons of the central nervous system, suggesting an immunological process possibly affecting vascular structures. Our experience suggests that IgG4-RD may be considered in patients with ischemic stroke and cerebral venous system involvement.