Adult type granulosa cell tumor causing precocious pseudopuberty in a 6 year-old girl

Isguven P., Yoruk A., Adal E., Arslanoglu I., Ilvan Ş. , Yildiz M.

Journal of Pediatric Endocrinology and Metabolism, vol.16, no.4, pp.571-573, 2003 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1515/jpem.2003.16.4.571
  • Title of Journal : Journal of Pediatric Endocrinology and Metabolism
  • Page Numbers: pp.571-573


Malignant ovarian tumors are responsible for 2-3% of all cases of precocious pseudopuberty (PP) in girls. The most common forms of ovarian tumors presenting as PP are the granulosa cell tumors (GCT). The clinical and pathological features of granulosa cell tumors that occur frequently in young girls, so-called juvenile granulosa cell tumors (JGCT), differ histologically from those occurring in adults. As a cause of PP in young girls, adult type granulosa cell tumors (AGCT) are extremely rare. We report a 6 year-old girl presenting with early breast development and vaginal bleeding due to a well encapsulated ovarian tumor. Microscopic features of the resected tumor were characteristic of AGCT.