Adult type granulosa cell tumor causing precocious pseudopuberty in a 6 year-old girl


Isguven P., Yoruk A., Adal E., Arslanoglu I., Ilvan S., Yildiz M.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.16, ss.571-573, 2003 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 16 Konu: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1515/jpem.2003.16.4.571
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Sayfa Sayısı: ss.571-573

Özet

Malignant ovarian tumors are responsible for 2-3% of all cases of precocious pseudo-puberty (PP) in girls. The most common forms of ovarian tumors presenting as PP are the granulosa cell tumors (GCT). The clinical and pathological features of granulosa cell tumors that occur frequently in young girls, so-called juvenile granulosa cell tumors (JGCT), differ histologically from those occurring in adults. As a cause of PP in young girls, adult type granulosa cell tumors (AGCT) are extremely rare. We report a 6 year-old girl presenting with early breast development and vaginal bleeding due to a well encapsulated ovarian tumor. Microscopic features of the resected tumor were characteristic of AGCT.