Value of cardiac markers in dogs with chronic mitral Disease


BAKIREL U. , ÜLGEN S.

Acta veterinaria, cilt.59, ss.223-0, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 59 Konu: 2
  • Basım Tarihi: 2009
  • Dergi Adı: Acta veterinaria
  • Sayfa Sayıları: ss.223-0

Özet

kronik mitral kapak hastalıklı köpeklerde kardiyak hasarın belirlenmesinde serum troponin I (cTnI), troponin T (cTnT), lactate dehydrogenase (LDH) and  CK isoenzimi MB'nin  (CK-MB) öneminin belirlenmesi için yapılan bu araştırmada bu parametrelerin önemli oranda yükselmesinin kardiyak hasarın şiddetinin ve hastalığın prognozunun belirlenmesinde kullanışlı olduğu sonucuna ulaşılmıştır.

 

The aim of this study was to assess the role of serum cardiac
troponin I (cTnI), troponin T (cTnT), lactate dehydrogenase (LDH) and
MB isoenzyme of CK (CK-MB) concentrations in the detection of
cardiac injury in dogs with chronic mitral valve disease (CMVD). Fiftyfive dogs with echocardiographic diagnosis of CMVD defined as
cardiac thrill (Ct) and non-cardiac thrill (nCt) by auscultation-palpation,
and ten control dogs were studied. Serum was extracted from a blood
sample from each dog. Analysis of serum cTnI, cTnT, LDH and CK-MB
concentrations were performed. Mean ± SD serum cTnI concentration
was 1.9 ± 0.38 ng/mL in group-Ct and 1.75 ± 0.27 ng/mL in group-nCt,
and cTnI concentrations in both the subgroups were significantly
higher than in the control dogs (P<0.01). cTnT and CK-MB
concentrations were 0.031 ± 0.02 ng/mL and 83.5 ± 88.4 IU/L in
group-Ct and 0.024 ± 0.01 ng/mL and 51.6 ± 47.4 IU/L in group-nCt,
respectively. Mean cTnT and CK-MB concentrations in group-Ct were
significantly higher than in control dogs (P<0.01, P<0.05). LDH
concentration was 918 ± 136.4 IU/L in group-Ct and 351 ± 140.7 IU/L
in group-nCt. A significant difference in serum LDH concentrations was
observed between the 3 studied groups (P<0.05). In this study,
compared with clinically healthy dogs, significant increases in serum
cTnI, cTnT, LDH and CK-MB concentrations were detected in dogs with
CMVD. The findings of this study indicate that the biochemical markers
activity elevated with severity of the disease in dogs with CMVD.
Measurement of cardiac troponins, as the newer markers than LDH and
CK-MB concentrations, may be useful in the detection of cardiac injury
and prognosis in dogs with CMVD