Pentraxin-3 levels are associated with vasculitis and disease activity in childhood-onset systemic lupus erythematosus


Şahin S., Adrovic A. , Barut K. , Durmus S. , Gelisgen R., Uzun H. , ...More

LUPUS, vol.26, no.10, pp.1089-1094, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 10
  • Publication Date: 2017
  • Doi Number: 10.1177/0961203317699286
  • Title of Journal : LUPUS
  • Page Numbers: pp.1089-1094
  • Keywords: Pentraxin-3, Childhood-onset systemic lupus erythematosus, Biomarker, SLEDAI, Vasculitis, COLLEGE, DAMAGE, SITES, PTX3

Abstract

Objectives Childhood-onset systemic lupus erythematosus (cSLE) is a multisystemic autoimmune disease characterized by inflammatory organ damage by means of vasculitis. Pentraxin-3 (PTX3) is expressed locally at the sites of inflammatory processes, predominantly from endothelial cells. In adult studies, PTX3 has shown to be an indicator of active vasculitis both in large-vessel and small-vessel vasculitides, as well as in SLE. Moreover, in SLE it has found to be correlated with disease activity, and with some of the clinical manifestations and laboratory parameters. We aimed to ascertain if PTX3 might be a significant mediator in cSLE and if it might indicate active vasculitis during the course of the disease.