Kruppel-Like Transcription Factor-4 Gene Expression and DNA Methylation Status in Type 2 Diabetes and Diabetic Nephropathy Patients


Coskun Z. M. , Ersoz M., Adas M., HANÇER V. S. , Boysan S. N. , Gonen M. S. , ...Daha Fazla

ARCHIVES OF MEDICAL RESEARCH, cilt.50, ss.91-97, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 50 Konu: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.arcmed.2019.05.012
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Sayfa Sayıları: ss.91-97

Özet

Background/Aim. Diabetic nephropathy (DN) is one of the most serious microvascular complications in diabetic patients. The kruppel-like transcription factor-4 (KLF-4) affects the expression of genes involved in the pathogenesis of DN. The present study aims to identify the KLF-4 expression and DNA methylation (DNAMe) status in patients with type-2 diabetes (T2D) and DN and to reveal the contribution of the KLF-4 to the development of DN.