A free radical scavenger (Tempol) and its effect on intimal hyperplasia of vein grafts in rats


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Turkmen A., Dogan M., Temel M.

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.24, ss.379-386, 2018 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 24 Konu: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5505/tjtes.2017.80281
  • Dergi Adı: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Sayfa Sayısı: ss.379-386

Özet

BACKGROUND: Reversed vein grafting exposes the vessel to a period of ischemia, reperfusion and subsequent reactive oxygen species, which may damage endothelial tissue, smooth muscle cell proliferation and later the development of intimal hyperplasia. Tempol is a free radical scavenger that permeates biological membranes. This study investigates the effects of a free radical scavenger (Tempol) on intimal hyperplasia of femoral vein grafts and the level of reactive oxygen species in rats.