In Vivo and In Vitro Antneoplastic Actions of Caffeic Acid Phenethyl Ester (CAPE): Therapeutic Perspectives


Akyol S., OZTURK G., GINIS Z., Armutcu F. , Yigitoglu M. R. , Akyol O.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, cilt.65, ss.515-526, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 65 Konu: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1080/01635581.2013.776693
  • Dergi Adı: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
  • Sayfa Sayısı: ss.515-526

Özet

Cancer prevention and treatment strategies have attracted increasing interest. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-B at M concentrations and shows ability to stop 5-lipoxygenase-catalyzed oxygenation of linoleic acid and arachidonic acid. Previous studies have demonstrated that CAPE exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and, most improtantly, antineoplastic properties. The primary goal of the present review is to summarize and critically evaluate the current knowledge regarding the anticancer effect of CAPE in different cancer types.

Cancer prevention and treatment strategies have attracted increasing interest. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-κB at μM concentrations and shows ability to stop 5-lipoxygenase-catalyzed oxygenation of linoleic acid and arachidonic acid. Previous studies have demonstrated that CAPE exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and, most improtantly, antineoplastic properties. The primary goal of the present review is to summarize and critically evaluate the current knowledge regarding the anticancer effect of CAPE in different cancer types.