Retrospective analysis of children with uveitis treated with infliximab


Tugal-Tutkun I., Ayranci O., Kasapcopur O. , Kir N.

JOURNAL OF AAPOS, vol.12, no.6, pp.611-613, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1016/j.jaapos.2008.08.007
  • Title of Journal : JOURNAL OF AAPOS
  • Page Numbers: pp.611-613

Abstract

Tumor necrosis factor-alpha (TNF-alpha) antagonists have been successfully used in refractory cases of pediatric uveitis.(1-7) We report our experience with the monoclonal anti-TNF-alpha antibody infliximab in the treatment of uveitis in 20 children. Twenty children with noninfectious uveitis were treated with infliximab as an initial line of immunomodulatory therapy (4 children) or for uncontrolled intraocular inflammation despite aggressive immunosuppressive therapy (16 children). Intraocular inflammation was controlled in the short term in all children; resistance developed in 4 children after long-term therapy.