The relationship between vitamin d levels and receptor activator of nuclear factor ligand in hashimoto’s thyroiditis Hashimoto Tiroiditinde Vitamin D Seviyeleri ile Reseptör Aktivatör Nükleer Kappa-B Ligandı Arasındaki İlişki


Creative Commons License

Yavuzer H. , Işık S., Cengiz M., Bolayırlı İ. M. , Döventaş A. , Erdinçler D. S.

Haseki Tip Bulteni, cilt.55, sa.4, ss.261-268, 2017 (Diğer Kurumların Hakemli Dergileri) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Konu: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/haseki.21931
  • Dergi Adı: Haseki Tip Bulteni
  • Sayfa Sayıları: ss.261-268

Özet

© 2017 by The Medical Bulletin of University of Health Sciences Haseki Training and Research Hospital.Aim: In order to analyze the relationship of Hashimoto’s thyroiditis with vitamin D and osteoclastogenic markers, we investigated vitamin D, osteoprotegerin (OPG) and receptor activator of nuclear factor ligand (RANKL) levels in patients over 60 years with and without Hashimoto’s thyroiditis. Methods: Eighty three female patients (49 with and 34 without Hashimoto’s thyroiditis), who attended the endocrinology and geriatrics departments between May 2013 and October 2013 were included in the study. Results: There was no statistically significant difference in the levels of vitamin D, OPG and RANKL between the groups. Vitamin D was significantly correlated with OPG and RANKL in patients with Hashimoto’s thyroiditis. In addition, a significant relationship was found between OPG and RANKL levels. Of the patients with Hashimoto’s thyroiditis, 33 were autoantibody-positive and 16 were negative. Vitamin D, OPG and RANKL levels were significantly lower in antibody-positive patients than in negative subjects. Conclucion: There were no differences in vitamin D, OPG and RANKL levels between patients with and without Hashimoto’s thyroidits. Autoantibody-positive Hashimoto’s thyroiditis group had statistically significantly lower vitamin D, OPG and RANKL levels. This reverse correlation suggests that autoantibodies may have an effect on osteoclastogenesis.