European Journal of Engineering and Applied Sciences, cilt.3, ss.19-36, 2020 (Hakemli Üniversite Dergisi)
Corneal wounds are caused by surgical infections and traumatic injuries. Traditionally, the nylon sutures are used to repair these corneal wounds. In order for the cornea to regain its structural integrity, more than one suture is usually required, depending on the shape and degree of the injury in the corneal wound. In ophthalmic surgery, tissue adhesives can be used instead of sutur es. Tissue adhesives have been developed as an alterna tive for suturing aids and for sealing injured tissues. Polymer based hydrogel systems, which can adhere to a tissue after crosslinking and are an important element in almost all surgeries worldwide, are applied as tissue adhesives. They are classified as internal and external according to the application conditions. External tissue adhesives are generally applied in topical applications such as wound closure and epidermal vaccination. On the other hand, internal tissue adhesives are used in intracorporeal conditions with direct contact to the internal environment including tissues, organs and body fluids such as chronic organ leak repair and reduction of bleeding complications. In this review study, tissue adhesives deve loped in the literature for ocular ap plications, commercial applications and application techniques of these adhesives are focused. Existing
tissue adhesives used for corneal incisions are discussed and complications, safety profiles and efficacy, synthesis methods and contents of these adhes ives are evaluated together.