Spices to Control COVID-19 Symptoms: Yes, but Not Only ...

Bousquet J., Czarlewski W., Zuberbier T., Mullol J., Blain H., Cristol J., ...More

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume:
  • Publication Date: 2020
  • Doi Number: 10.1159/000513538
  • Keywords: Nuclear factor (erythroid-derived 2)-like 2, Transient receptor potential ankyrin 1, Transient receptor potential vanillin 1, COVID-19, Spices, Fermented vegetables, HEALTH-BENEFITS, CHANNEL, NRF2, RECEPTOR, TRPA1, ACTIVATION, CAPSAICIN, DESENSITIZATION, ISOTHIOCYANATE, MODULATION


There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway. (c) 2020 S. Karger AG, Basel