Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey


Ozbek U., Sirma S., Agaoglu L., Yuksel L., Anak S., Yildiz I., et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.25, ss.204-208, 2003 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 25 Konu: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1097/00043426-200303000-00005
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Sayfa Sayısı: ss.204-208

Özet

Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey.