pK(a) Constant of Varenicline


ÜNAL G., Yeloglu I. , Anilanmert B., NARİN İ.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, cilt.57, ss.14-17, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 57 Konu: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1021/je200405w
  • Dergi Adı: JOURNAL OF CHEMICAL AND ENGINEERING DATA
  • Sayfa Sayısı: ss.14-17

Özet

The pK(a) constant of varenicline using a partial agonist of the nicotinic alpha 4 beta 2 acetylcholine receptor was determined potentiometrically. The pK(a) constant of varenicline was calculated as 9.22 (+/- 0.13) at I = 0.15 (NaCl), 25 +/- 1 degrees C using the Irving-Rossotti method. The experimental results were compared with theoretical ones obtained via the SPARC pK(a) calculation program. The distribution of species of the drug molecule at various pH values was demonstrated to provide experimental data of its pK(a), to be used in commenting on its biological uptake, the binding of these molecules to environmental matrices, forming chelates with metallic cations, and its analysis.