The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression


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Bayoglu B. , Arslan C., Gode S. , Dagistanli F. , Arapi B., Deser S. B. , ...More

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, vol.21, no.7, pp.659-671, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.5551/jat.21774
  • Title of Journal : JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
  • Page Numbers: pp.659-671

Abstract

Aim: The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16(INK4a) inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression in vascular smooth muscle cells (VSMCs) and may modulate the early stages of atherosclerosis. Therefore, we aimed to study the expression of the INK4/ARF locus genes CDKN2A and CDKN2BAS in order to examine the p16INK4a protein expression and the level of cell proliferation in carotid plaques and saphenous tissue samples.