Iron supplementation in experimental hyperthyroidism: Effects on oxidative stress in skeletal muscle tissue


Creative Commons License

Seymen H. O. , Civelek S. , Seven A. N. , Yigit G. , Hatemi H. H. , Burcak G.

YONSEI MEDICAL JOURNAL, cilt.45, sa.3, ss.413-418, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.3349/ymj.2004.45.3.413
  • Dergi Adı: YONSEI MEDICAL JOURNAL
  • Sayfa Sayıları: ss.413-418

Özet

This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to cause an increase in thiobarbituric acid-reactive substances (TBARS) and copper zinc superoxide dismutase (Cu, Zn SOD) activity, but decreases in the glutathione-peroxidase (GSH Px) activity and glutathione (GSH). Iron supplementation caused an increase in TBARS and a decrease in GSH. Iron supplementation in hyperthyroid rats attenuated the hyperthyroid state, but lowered the plasma ferritin level, which is considered an indicator of thyroid hormone action. Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD.